By Michael Breitenbach, Reto Crameri, Samuel B. Lehrer

The significance of fungal organisms as allergens and pathogens has been expanding significantly during the last decade. this is often due, at the one hand, to a basic bring up within the prevalence of bronchial asthma, but additionally to the turning out to be variety of immunocompromized members corresponding to AIDS sufferers or transplant recipients. This e-book summarizes what's presently recognized concerning the allergens of Candida, Aspergillus, Cladosporium, Alternaria, Coprinus, and Psilocybe, between others, and describes the applying of recombinant allergens for prognosis and new different types of remedy. The virulence components and safeguard mechanisms opposed to Aspergillus and Candida infections are mentioned as are a number of the explanations of superficial epidermis infections with fungi and the aerobiology of fungal spores and mycelia. A finished bankruptcy on fungal pollution and their significance for human and animal well-being is incorporated, via a precis of the current nation of fungal genome sequencing.

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Twelve (32%) patients showed a positive skin reaction either to Coprinus spore extract or ground Coprinus cap in Vaseline. The lesions that were evoked were consistent by histologic and immunohistochemical findings with acute atopic eczema. A few subjects reacted solely to the Coprinus extract. Similar results were obtained with P. pulmonarius spore extracts [30]. These data indicate that basidiomycete allergens can induce eczematous skin lesions in individuals with atopic dermatitis, although the clinical relevance of positive atopy patch tests to aeroallergens is not completely elucidated.

47] found Levetin/Horner 22 that the relative risk of developing asthma was significantly related to basidiospore sensitivity. These studies clearly illustrate the clinical importance of basidiospores as well as other fungal spores as triggers of allergic disease. There is currently great interest and active debate about the health effects of indoor mold exposure. Over the last 10–15 years, numerous studies documented an association between damp and/or moldy indoor environments and an increased prevalence of respiratory complaints.

Delfino RJ, Coate BD, Zieger RS, Seltzer JM, Street DH, Koutrakis P: Daily asthma severity in relation to personal ozone exposure and outdoor fungal spores. Am J Respir Crit Care Med 1996; 154:633–641. Levetin/Horner 26 43 44 45 46 47 48 49 50 51 52 53 54 Delfino RJ, Zieger RS, Seltzer JM, Street DH, Matteucci RM, Anderson PR, Koutrakis P: The effect of outdoor fungal spore concentrations on daily asthma severity. Environm Health Perspect 1997;105:622–635. Epton MJ, Martin IR, Graham P, Healy PE, Smith H, Balasubramaniam R, Harvey IC, Fountain DW, Hedley J, Town GI: Climate and aeroallergen levels in asthma: A 12-month prospective study.

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