By Julius A. (editor); Gordon, Maxwell (editor) Vida

content material: Virus-receptor interactions / Bernard N. Fields and Mark I. Greene --
layout of peptide superagonists and antagonists : conformational and dynamic concerns / Victor J. Hruby --
Localization and synthesis of protein antigenic websites : use of loose artificial peptides for the guidance of antibodies and T-cells of preselected specificities / M. Zouhair Atassi --
reviews on new microbial secondary metabolites with capability usefulness : antibiotics, enzyme inhibitors, and immunomodifiers / Hamao Umezawa --
Conformation of nucleic acids and their interactions with medications / Andrew H.-J. Wang --
Substrate analog inhibitors of hugely particular proteases / James Burton --
Structure-behavioral task relationships of peptides derived from ACTH : a few stereochemical issues / J.W. Van Nispen and H.M. Greven --
layout of novel cyclic hexapeptide somatostatin analogs from a version of the bioactive conformation / Roger M. Freidinger and Daniel F. Veber --
layout of kinase inhibitors : conformational and mechanistic concerns / George L. Kenyon and Rebecca E. Reddick --
layout and discovery of aspartyl protease inhibitors : mechanistic and medical implications / Daniel H. wealthy, Francesco G. Salituro, Mark W. Holladay, and Paul G. Schmidt --
layout of peptide analogs : theoretical simulation of conformation, energetics, and dynamics / R.S. Struthers, A.T. Hagler, and J. Rivier.

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Nature 1975, 258, 577-579. 32. ; Cuatrecasas, P. Vitamins and Hormones 1978, 36, 297-382. 33. H. Peptides, 1982, 3, 1039-1072. 34. ; Hughes, J . W. Nature 1977, 267, 495-499. 35. W. Proc. Natl. Acad. S c i . USA 1981, 78, 6181-6185. 36. ; Cuatrecasas, P. J . B i o l . Chem. 1979, 254, 2610-2618. 37. Sarantakls, D. S. Patent 4 148 789, 1979. 38. ; DiMaio, J . M-D. Biochem. Biophys. Res. Commun. 1981, 101, 337-343. 39. R. Proc. Natl. Acad. S c i . USA 1977, 74, 1373-1377. 40. I. Biochem. Biophys.

The dotted portions represent parts of the molecule which have been shown exhaustively to reside outside antigenic sites (1). ; ACS Symposium Series; American Chemical Society: Washington, DC, 1984. ATASSl Protein Antigenic Sites and Free Synthetic Peptides Site 1: Site 2: 15 16 21 22 (Ala)-Lys-Val-Glu-Ala-Asp-Val-(Ala) 56 6 Lys-Ala-Ser-Glu-Asp-Leu-Lys Site 3: 94 99 100 Ala-Thr-Lys-H1s-Lys-Ile-[Pro] Site 4: 113 119 120 His-Val-Leu-His-Ser-Arg-His-[Pro] Site 5: 145 151 (Lys)-Tyr-Lys-Glu-Leu-Gly-Tyr Figure 2.

L i f e Sciences, i n press, 1983. 43. F. Proc. Natl. Acad. S c i . USA, i n press, 1983. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1984. 2. 44. 45. 46. 47. 48. 49. 50. I,; Hurst. F. L i f e Sciences, i n press, 1983. M. Int. J . Peptide Protein Res. 1980, 16, 372-381. H. Int. J . Peptide Protein Res. 1980, 16, 382-391. Chan, W. J. Endocrinology 1982, 111, 48-54. J. ; Pierce Chem. : Rockford, 1983, i n press. J. Science 1981, 213, 1025-1027. Sawyer, T. ; Hruby, V. J . ; Hadley, M.

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