Chapter I basic houses and constitution of the Imidazoles (pages 3–31):
Chapter II The Alkyl? and Arylimidazoles (pages 33–54):
Chapter III The Oxo? and Hydroxyimidazoles and their Sulfur Analogues (pages 55–110):
Chapter IV The Halogenoimidazoles (pages 111–125):
Chapter V The Nitro?, Arylazo?, and Aminoimidazoles (pages 127–173):
Chapter VI The Imidazolecarboxylic and Sulfonic Acids (pages 175–211):
Chapter VII The Imidazolines, 2?Imidazolidones, 2?Imida?Zolidinethiones, 2?Iminoimidazolidines, and Imidazolidines (pages 213–245):
Chapter VIII The Benzimidazoles (pages 247–324):
Chapter IX Imidazoles (pages 327–367):
Chapter X Imidazolines (pages 367–373):
Chapter XI Imidazolidines (pages 373–376):
Chapter XII Imidazolidines, Imidazolidinethiones, and 2?Imidazolidones (pages 376–379):
Chapter XIII Benzimidazoles (pages 379–401):
Read or Download Chemistry of Heterocyclic Compounds: Imidazole and Its Derivatives, Part I, Volume 6 PDF
Similar chemistry books
Acronycine, a powerful antitumor agent, was once found within the bark of the small Australian Rutaceous tree, Acronychia baueri Schott. This new paintings offers a finished survey of the isolation, constitution choice, equipment of synthesis, and the organic houses of acronycine, in addition to an account of average and artificial analogues of acronycine, and their organic homes.
Content material: bankruptcy I normal houses and constitution of the Imidazoles (pages 3–31): bankruptcy II The Alkyl? and Arylimidazoles (pages 33–54): bankruptcy III The Oxo? and Hydroxyimidazoles and their Sulfur Analogues (pages 55–110): bankruptcy IV The Halogenoimidazoles (pages 111–125): bankruptcy V The Nitro? , Arylazo?
- Organic Reactions vol.II
- Reducing the Time from Basic Research to Innovation in the Chemical Sciences: A Workshop Report to the Chemica Sciences Roundtable
- Comprehensive Medicinal Chemistry II, Volume 5 : ADME-Tox Approaches
- Analytical Profiles of Drug Substances, Vol. 1
- Nanoscale Materials in Chemistry, Second edition
- Handbook of Thermodynamic Diagrams, Volume 2 : Organic Compounds C5 to C7 (Vol 2) (Library of Physico-Chemical Property Data)
Extra info for Chemistry of Heterocyclic Compounds: Imidazole and Its Derivatives, Part I, Volume 6
It doea not, however, establish the tautomeric character of the imidasoles, as a difference in stability of the two isomers might also favor the formation of only one compound. The virtually tautomeric character of 4 (or 5 )-methylimidaaole follows from its behavior on methylation, leading to the formation of a mixture, separable by distillation, of 1,&dimethyl- and 1,4dimethylimidazole (66,67). Thus the compound reacts as if it were a mixture of 4-methyl- and 5-methylimidseole. l-DimcthylimidnzoIc Iiiiidazoles containing a, free iiiiino lrytlrogcn arc thus virtually bausystem and react like tautoriieric iiiixtures of the two possible Corms.
The compound melts at 275O, distils without decomposition, and exhibits great chemical stability, especially under acid conditions. The addition of metals or metal aniides to its solution in liquid ammonia results in the formation of salts (70). These hydrolyze when dissolved in water with the formation of lophinc and a metal hydroxide. Exposure 11. Alkyl- and Arylimidazoles . 47 to hydrogen iodide at 300" brings about a slow conversion of lophine into benzoic acid (71); treatment with sodium in alcohol leaves the compound unchanged (53).
O=x-j NHs 3/ \ N Lophine tended it t o the preparation of simpler imidazoles and demonstrated its general applicability. It occurred to him that the formation of imidazole from glyoxal and ammonia, as discovered by Debus (3), might proceed in a manner similar t o the lophine synthesis, imidazole formation being due to tlie interaction of (tiiiiuonia, glyoxal, and foriiialdehydc. The formaldehyde, he reasoned, might arise from the cleavage of the glyoxal 33 34 Chemistry of Classes and Derivatives under the influence of ammonia.