By Nurullah Saracoglu (auth.), Mahmud Tareq Hassan Khan (eds.)

N. Saracoglu: Functionalization of Indole and Pyrrole Cores through Michael variety Additions.-

J. C. Menéndez: Chemistry of the Welwitindolinones.-

G. Topcu, O. Demirkiran: Lignans from Taxus Species.-

S. Süzen: Antioxidant actions of man-made Indole Derivatives and attainable task Mechanisms.-

M. González, H. Cerecetto, A. Monge: Quinoxaline 1,4-dioxide and Phenazine 5,10-dioxide Chemistry and Biology.-

M.T.H. Khan: Quinoline Analogues as Anti-angiogenic brokers and Telomerase Inhibitors

Y. Liu, S. Zhang, J.H. Jung, T. Xu: Bioactive Furanosesterterpenoids from Marine Sponge.-

C.A. Pujol, M.J. Carlucci, M.C. Matulewicz, E.B. Damonte: normal Sulfated Polysaccharides for the Prevention and keep watch over of Viral Infections.-

N. Hamdi, M. Saoud, A. Romerosa: 4-Hydroxy Coumarine: a flexible Reagent for the Synthesis of Heterocyclic and Vanillin Ether Coumarins with organic Activities.-

I. Orhan, B. Özcelik, B. Sener: present results of Antiviral and Antimicrobial assessment of a few Heterocyclic Compounds from Turkish Plants

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Saracoglu Scheme 50 silica gel, which acts as a mild acidic catalyst, under microwave irradiation or room temperature gave unsymmetrical bis(indolyl)nitroethanes (236a–h) in excellent yields (69–86%) (Scheme 51 and Table 6). But, the conjugate addition of the indole derivatives 233–235 with 227 failed. This situation was attributed to the fact that silica gel is not sufficiently acidic to catalyze the desired Michael addition. In order to overcome this difficulty, the reactions of 2, 14, 19 and 228–235 with 220 were performed in acetonitrile under reflux using p-TsOH (25% wt) as the catalyst.

Saracoglu Scheme 50 silica gel, which acts as a mild acidic catalyst, under microwave irradiation or room temperature gave unsymmetrical bis(indolyl)nitroethanes (236a–h) in excellent yields (69–86%) (Scheme 51 and Table 6). But, the conjugate addition of the indole derivatives 233–235 with 227 failed. This situation was attributed to the fact that silica gel is not sufficiently acidic to catalyze the desired Michael addition. In order to overcome this difficulty, the reactions of 2, 14, 19 and 228–235 with 220 were performed in acetonitrile under reflux using p-TsOH (25% wt) as the catalyst.

The alkylation of indole with trans-β-nitrostyrene in toluene at room temperature has been accomplished with 110d-Zn(OTf)2 or 113-Zn(OTf)2 as the catalyst. The obtained results show that the NH group in ligands 110–112 is crucial. Indole Scheme 31 22 N. Saracoglu π-interaction with the NH group between two phenyl groups would direct the indole to attack the nitroalkenes preferentially. Enantioselective additions of α,β-unsaturated 2-acyl imidazoles, catalyzed by bis(oxazolinyl)pyridine–scandium(III)triflate complex, were used for the asymmetric synthesis of 3-substituted indoles.

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